UMS member Dr Ayis, along with colleagues, publishes in Diabetes & Vascular Disease Research, a paper titled ‘Effects of aliskiren on mortality, cardiovascular outcomes and adverse events in patients with diabetes and cardiovascular disease or risk: A systematic review and meta-analysis of 13,395 patients‘.
The study aimed ‘to investigate the efficacy and safety of aliskiren in patients with diabetes and increased cardiovascular risk or established cardiovascular disease’. The systematic review and meta-analysis concluded that ‘patients with diabetes and cardiovascular disease or cardiovascular risk do not benefit from the addition of aliskiren to standard medical therapy’.
Professor Janet Peacock & colleagues investigated the relationship between unmetabolized folic acid (UFA), tetrahydrofolate and colorectal adenoma risk.
The new study published in Cancer Prevention Research was an extension of the analysis of a previously published RCT. The new study, using post hoc analysis, found that ‘during the later follow-up period in which folic acid supplementation was previously seen to increase the risk of advanced and multiple adenomas, higher serum methylated folates was associated with a higher risk of multiple and/or advanced adenomas, but no clear indication that UFA played a direct role’.
UMS member, Dr Salma Ayis along with colleagues at Kings College Hospital, Imperial College and Kings College London have recently published a study in BMJ Heart titled: ‘Drug treatment effects on outcomes in heart failure with preserved ejection fraction: a systematic review and meta-analysis’
The systematic review and meta-analysis investigated pharmacological treatments in patients with heart failure with left ventricular ejection fraction. The research concluded that ‘the efficacy of treatments in patients with heart failure and an LV ejection fraction ≥40% differ depending on the type of therapy, with beta-blockers demonstrating reductions in all-cause and cardiovascular mortality’.
UMS members Odile Sauzet (associate) and Janet Peacock have published a study titled:
The study used stimulated data on a dataset of preterm infants to investigate ‘the performance of several approaches to the analysis of binomial outcomes in the presence of some clusters of size two’. The study found ‘that the number of covariates or the level two variance do not necessarily affect the performance of the various methods used to analyse datasets containing twins but when the percentage of small clusters is too small, mixed models cannot capture the dependence between siblings’.
Janet Peacock has published, along with colleagues in London, UK, a study titled:
The study published in the European Journal of Pedicatrics aimed to ‘test the hypothesis that neurally adjusted ventilatory assist (NAVA) compared to assist control ventilation (ACV) would result in a lower OI in infants with evolving or established BPD’. The study undertaken at Kings College Hopsital London, concluded that ‘NAVA compared to ACV improved oxygenation in prematurely born infants with evolving or established bronchopulmonary dysplasia (BPD)’.
A study investigating unmetabolized folic acid (UFA), Tetrahydrofolate and Colorectal Adenoma Risk was conducted by researchers in the US, Canada and the UK, including UMS member, Professor Janet Peacock.
The study based on a earlier randomized trial concluded that ‘during the later follow-up period in which folic acid supplementation was previously seen to increase the risk of advanced and multiple adenomas, higher serum mF (methylated folates) was associated with a higher risk of multiple and/or advanced adenomas, but no clear indication that UFA played a direct role’.
UMS member, Professor Peacock along with colleagues in the UK and Netherlands have published in Acta Neurologica Scandinavica a study titled:
The study sought to ‘generate explanatory hypotheses about the co-occurrence of so- matic comorbidities and epilepsy, avoiding causal and treatment-resultant biases’. The authors concluded that ‘Somatic comorbidities do not occur randomly in relation to epilepsy; having more severe epilepsy seems to be a risk factor’.
Professor Peacock along with colleagues in the US have published a study titled:
The Randomized Control Trial concluded that ‘benefits from vitamin D3 supplementation for the prevention of advanced colorectal adenomas may vary according to vitamin D receptor genotype’.
Rachel Phillips gave a talk titled “Lessons to learn from the reporting of adverse events (AEs) in randomised controlled trials published in high impact journals” and a poster presentation titled “Overview of statistical methods to monitor harms during the conduct of a randomised controlled trial”.
This research was presented at the 4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials in Liverpool, UK, 7-10 May 2017
Dr Douiri, along with other colleagues from King’s College Hospital NHS Foundation trust and King’s College London, have published as study titled:
Composite biomarker panel for prediction of severity and diagnosis of acute GVHD with T-cell-depleted allogeneic stem cell transplants—single centre pilot study
The study published in the Journal of Clinical Pathology evaluated the ‘clinical utility of a composite biomarker panel to help identify individuals at risk of developing aGVHD, and to help predict and differentiate between severity of aGVHD following T-cell-depleted allogeneic HSCT’.
The retrospective cohort study concluded that the ‘pilot data support the usefulness of these composite biomarker panels in the prediction of severity and diagnosis of aGVHD in patients undergoing T-cell-depleted reduced intensity allogeneic HSCT’.
UMS member Dr Abdel Douiri, along wiht co-authors, publishes this week in Thorax, a study titled:
Physiotherapy, and speech and language therapy intervention for patients with refractory chronic cough: A multicentre randomised control trial
This RCT study of patients with refractory chronic cough investigated ‘the efficacy of a physiotherapy, and speech and language therapy intervention (PSALTI) to improve health-related quality of life (HRQoL) and to reduce cough frequency in patients with refractory chronic cough’
The authors concluded that ‘greater improvements in HRQoL and cough frequency were observed with PSALTI intervention’ and that the ‘findings support the use of PSALTI for patients with refractory chronic cough.
A big congratulations to UMS’s own Dr Mercy Ofyua, has been awarded her PhD: ‘Dichotomisation of Continuous Outcomes in Medical Research’.
Congratulations to UMS member, Professor Janet Peacock, who has been appointed a National Institute Health Research (NIHR) Senior Investigator.
Read more about this great achievement here=
Rachel Phillips, along with colleagues, published this week in JAMA Psychiatry a meta-analysis study titled: Efficacy of Self-guided Internet-Based Cognitive Behavioral Therapy in the Treatment of Depressive Symptoms: A Meta-analysis of Individual Participant Data
The study aimed to ‘estimate the effect of self-guided internet-nased cognitive behavioural therapy (iCBT) in treating adults with depressive symptoms compared with controls and evaluate the moderating effects of treatment outcome and response’.
The authors concluded through thier extensive meta-analysis that ‘self-guided iCBT is effective in treating depressive symptoms’.
UMS member, Professor Peacock, publishes with collaborators from Dartmouth College US , a study which shows evidence that the benefits of vitamin D supplementation for the prevention of colorectal cancer varies according to vitamin D receptor genotype.
The study, titled ‘Vitamin D Receptor Genotype, Vitamin D3 Supplementation,and Risk of Colorectal Adenomas: A Randomized Clinical Trial’, has been published in JAMA Oncology.
UMS members, Dr Ayis and Professor Peacock, along with colleagues, publish in Shock this month. The study is titled: ‘Cardiac troponin release is associated with biomarkers of inflammation and ventricular dilatation during critical illness’.
The observational cohort study enrolled adult patients who were in Intensive Care Units (ICU) in two hospitals for non-caridac reasons. The study explored the possible ‘association between cardiac troponin T (cTnT) and biomarkers of systemic inflammation and ventricular dilatation’.
The authors concluded that ‘in ICU patients admitted for non-cardiac reasons, serial cTnT levels were independently associated with markers of systemic inflammation and NT-proBNP’.
Published in European Psychiatry, Dr Ayis, along with colleagues have investigated the ‘Cardiovascular risk factors among patients with schizophrenia, bipolar, depressive, anxiety, and personality disorder‘.
The authors concluded that ‘cardiovascular risk factors require special clinical attention among patients with psychiatric disorders. Further research could study the effect of antidepressants and antipsychotics on cardiovascular risk factors‘.
MedStats team member, Dr Ayis, along with colleagues publishes researching ‘Assessing the relationship between chronic pain and cardiovascular disease: A systematic review and meta-analysis‘.
The authors concluded that their ‘review supports a possible dose-response type of association between chronic pain and cardiovascular disease, supported by a range of observational studies originating from different countries‘.
MedStats team member, Dr Douiri, along with colleagues publishes study titled: ‘A prediction model for the response to oral labetalol for the treatment of antenatal hypertension’.
The study used a prospective observational design to ‘identify at presentation the maternal hemodynamic and demographic variables associated with a therapeutic response to oral labetalol and to use these variables to develop a prediction model to anticipate the response to labetalol monotherapy in women with hypertension’. The authors concluded that ‘maternal demographics and haemodynamics are potent predictors for the response to labetalol, and these parameters may guide therapy to enable effective blood pressure control and a lowering of severe hypertension rates’.
MedStats team members, Dr Peacock and Dr Douiri publish a study titled: ‘Intradermal Grass Pollen Allergen Immunotherapy for Seasonal Allergy: A Randomized Controlled Trial’
The study aimed to ‘evaluate the efficacy and safety of grass pollen intradermal immunotherapy in the treatment of allergic rhinitis’. Using a randomized control trial, the authors concluded that ‘intradermal allergen immunotherapy suppressed skin late responses but was not clinically effective and resulted in worsening of respiratory allergic symptoms’.