A 100 years ago today a ‘Death Ship’ from NZ arrived in Samoa – work by Dr Summers

Dr Summers and co-authors in New Zealand have published a blog detailing the arrival of a ‘Death Ship’ 100 years ago into Apia, Samoa on the 7th November 1918. This ship brought with it the 1918 influenza pandemic H1N1 strain Western Samoa (along with Fiji and Tonga), and resulted in loss of 22% the adult population in Western Samoa.

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The authors discuss these events and the impact on other Pacific nations, along with recommendations for the New Zealand Government to develop stronger regional pandemic controls for the Pacific.

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Dr Summers investigates the health impact of WW1

A new study co-authored by MedStats member Dr Summers has been published in the Australian and New Zealand Journal of Public Health:

https://onlinelibrary.wiley.com/doi/full/10.1111/1753-6405.12837

The study investigates the health impacts on both military and civilian peoples in New Zealand following WW1. Aspects of mortality and morbidity are explored, such as the injuries from conflict, psychological impacts, and health inequalities in terms of health outcomes.

Further media links include:

https://www.nzherald.co.nz/nz/news/article.cfm?c_id=1&objectid=12150958

https://www.odt.co.nz/news/dunedin/campus/university-of-otago/war-kept-killing-after-1918-study

Dr Ayis leads on new study published in Journal of Affective Disorders

UMS member Dr Salma Ayis along with colleagues has published a new study titled:

‘Evaluation of the Hospital Anxiety and Depression Scale (HADS) in screening stroke patients for symptoms: Item Response Theory (IRT) analysis’

The study published in the Journal of Affective Disorders ‘examined the properties of each item of HADS [Hospital Anxiety and Depression scale] as perceived by stroke patients, and assessed the information these items convey about anxiety and depression between 3 months to 5 years after stroke’.

The authors concluded that ‘a more concise selection of items based on their properties, would provide a precise approach for screening patients and for an optimal allocation of patients into clinical trials’.

Dr Ayis publishes in Diabetes & Vascular Disease Research

UMS member Dr Ayis, along with colleagues, publishes in Diabetes & Vascular Disease Research, a paper titled ‘Effects of aliskiren on mortality, cardiovascular outcomes and adverse events in patients with diabetes and cardiovascular disease or risk: A systematic review and meta-analysis of 13,395 patients‘.

The study aimed ‘to investigate the efficacy and safety of aliskiren in patients with diabetes and increased cardiovascular risk or established cardiovascular disease’. The systematic review and meta-analysis concluded that ‘patients with diabetes and cardiovascular disease or cardiovascular risk do not benefit from the addition of aliskiren to standard medical therapy’.

UMS member Prof Peacock publishes in Cancer Prevention Research

Professor Janet Peacock & colleagues investigated the relationship between unmetabolized folic acid (UFA), tetrahydrofolate and colorectal adenoma risk.

The new study published in Cancer Prevention Research was an extension of the analysis of a previously published RCT. The new study, using post hoc analysis, found   that ‘during the later follow-up period in which folic acid supplementation was previously seen to increase the risk of advanced and multiple adenomas, higher serum methylated folates was associated with a higher risk of multiple and/or advanced adenomas, but no clear indication that UFA played a direct role’.

Dr Ayis publishes in BMJ Heart

UMS member, Dr Salma Ayis along with colleagues at Kings College Hospital, Imperial College and Kings College London have recently published a study in BMJ Heart titled: ‘Drug treatment effects on outcomes in heart failure with preserved ejection fraction: a systematic review and meta-analysis’

The systematic review and meta-analysis investigated pharmacological treatments in patients with heart failure with left ventricular ejection fraction. The research concluded that ‘the efficacy of treatments in patients with heart failure and an LV ejection fraction ≥40% differ depending on the type of therapy, with beta-blockers demonstrating reductions in all-cause and cardiovascular mortality’.

Professor Peacock publishes in BMC Medical Research Methodology

UMS members Odile Sauzet (associate) and Janet Peacock have published a study titled:

The study used stimulated data on a dataset of preterm infants to investigate ‘the performance of several approaches to the analysis of binomial outcomes in the presence of some clusters of size two’. The study found ‘that the number of covariates or the level two variance do not necessarily affect the performance of the various methods used to analyse datasets containing twins but when the percentage of small clusters is too small, mixed models cannot capture the dependence between siblings’.

 

UMS member Janet Peacock continues her work on ventilation methods in infants

Janet Peacock has published, along with colleagues in London, UK, a study titled:

 

The study published in the European Journal of Pedicatrics aimed to ‘test the hypothesis that neurally adjusted ventilatory assist (NAVA) compared to assist control ventilation (ACV) would result in a lower OI in infants with evolving or established BPD’. The study undertaken at Kings College Hopsital London, concluded that ‘NAVA compared to ACV improved oxygenation in prematurely born infants with evolving or established bronchopulmonary dysplasia (BPD)’.

Janet Peacock publishes in Cancer Prevention Research

A study investigating unmetabolized folic acid (UFA), Tetrahydrofolate and Colorectal Adenoma Risk was conducted by researchers in the US, Canada and the UK, including UMS member, Professor Janet Peacock.

The study based on a earlier randomized trial concluded that ‘during the later follow-up period in which folic acid supplementation was previously seen to increase the risk of advanced and multiple adenomas, higher serum mF (methylated folates) was associated with a higher risk of multiple and/or advanced adenomas, but no clear indication that UFA played a direct role’.

Professor Peacock study investigating Epilepsy

UMS member, Professor Peacock  along with colleagues in the UK and Netherlands have published in Acta Neurologica Scandinavica a study titled:

 

The study sought to ‘generate explanatory hypotheses about the co-occurrence of so- matic comorbidities and epilepsy, avoiding causal and treatment-resultant biases’. The authors concluded that ‘Somatic comorbidities do not occur randomly in relation to epilepsy; having more severe epilepsy seems to be a risk factor’.

UMS member, Rachel Phillips presents at the 4th International Clinical Trials Methodology Conference

Rachel Phillips gave a talk titled “Lessons to learn from the reporting of adverse events (AEs) in randomised controlled trials published in high impact journals” and a poster presentation titled “Overview of statistical methods to monitor harms during the conduct of a randomised controlled trial”.

This research was presented at the 4th International Clinical Trials Methodology Conference (ICTMC) and the 38th Annual Meeting of the Society for Clinical Trials in Liverpool, UK, 7-10 May 2017

UMS member, Dr Douiri publishes in Journal of Clinical Pathology

Dr Douiri, along with other colleagues from King’s College Hospital NHS Foundation trust and King’s College London, have published as study titled:

Composite biomarker panel for prediction of severity and diagnosis of acute GVHD with T-cell-depleted allogeneic stem cell transplants—single centre pilot study

The study published in the Journal of Clinical Pathology evaluated the ‘clinical utility of a composite biomarker panel to help identify individuals at risk of developing aGVHD, and to help predict and differentiate between severity of aGVHD following T-cell-depleted allogeneic HSCT’.

The retrospective cohort study concluded that the ‘pilot data support the usefulness of these composite biomarker panels in the prediction of severity and diagnosis of aGVHD in patients undergoing T-cell-depleted reduced intensity allogeneic HSCT’.

 

Dr Douri publishes research in Thorax

UMS member Dr Abdel Douiri, along wiht co-authors, publishes this week in Thorax, a study titled:

Physiotherapy, and speech and language therapy intervention for patients with refractory chronic cough: A multicentre randomised control trial

This RCT study of patients with refractory chronic cough investigated ‘the efficacy of a physiotherapy, and speech and language therapy intervention (PSALTI) to improve health-related quality of life (HRQoL) and to reduce cough frequency in patients with refractory chronic cough’

The authors concluded that ‘greater improvements in HRQoL and cough frequency were observed with PSALTI intervention’ and that the ‘findings support the use of PSALTI for patients with refractory chronic cough.

UMS member Rachel Phillips publishes in JAMA Psychiatry

Rachel Phillips, along with colleagues, published this week in JAMA Psychiatry a meta-analysis study titled: Efficacy of Self-guided Internet-Based Cognitive Behavioral Therapy in the Treatment of Depressive SymptomsA Meta-analysis of Individual Participant Data

The study aimed to ‘estimate the effect of self-guided internet-nased cognitive behavioural therapy (iCBT) in treating adults with depressive symptoms compared with controls and evaluate the moderating effects of treatment outcome and response’.

The authors concluded through thier extensive meta-analysis that ‘self-guided iCBT is effective in treating depressive symptoms’.

Professor Peacock publishes in JAMA Oncology

UMS member, Professor Peacock, publishes with collaborators from Dartmouth College US , a study which shows evidence that the benefits of vitamin D supplementation for the prevention of colorectal cancer varies according to vitamin D receptor genotype.

The study, titled ‘Vitamin D Receptor Genotype, Vitamin D3 Supplementation,and Risk of Colorectal Adenomas: A Randomized Clinical Trial’, has been published in JAMA Oncology.

Dr Ayis and Prof Peacock publish in Shock

UMS members, Dr Ayis and Professor Peacock, along with colleagues, publish in Shock this month. The study is titled: ‘Cardiac troponin release is associated with biomarkers of inflammation and ventricular dilatation during critical illness’.

The observational cohort study enrolled adult patients who were in Intensive Care Units (ICU) in two hospitals for non-caridac reasons. The study explored the possible ‘association between cardiac troponin T (cTnT) and biomarkers of systemic inflammation and ventricular dilatation’.

The authors concluded that ‘in ICU patients admitted for non-cardiac reasons, serial cTnT levels were independently associated with markers of systemic inflammation and NT-proBNP’.