Dr Douiri, along with other colleagues from King’s College Hospital NHS Foundation trust and King’s College London, have published as study titled:
Composite biomarker panel for prediction of severity and diagnosis of acute GVHD with T-cell-depleted allogeneic stem cell transplants—single centre pilot study
The study published in the Journal of Clinical Pathology evaluated the ‘clinical utility of a composite biomarker panel to help identify individuals at risk of developing aGVHD, and to help predict and differentiate between severity of aGVHD following T-cell-depleted allogeneic HSCT’.
The retrospective cohort study concluded that the ‘pilot data support the usefulness of these composite biomarker panels in the prediction of severity and diagnosis of aGVHD in patients undergoing T-cell-depleted reduced intensity allogeneic HSCT’.
UMS member Dr Abdel Douiri, along wiht co-authors, publishes this week in Thorax, a study titled:
Physiotherapy, and speech and language therapy intervention for patients with refractory chronic cough: A multicentre randomised control trial
This RCT study of patients with refractory chronic cough investigated ‘the efficacy of a physiotherapy, and speech and language therapy intervention (PSALTI) to improve health-related quality of life (HRQoL) and to reduce cough frequency in patients with refractory chronic cough’
The authors concluded that ‘greater improvements in HRQoL and cough frequency were observed with PSALTI intervention’ and that the ‘findings support the use of PSALTI for patients with refractory chronic cough.
A big congratulations to UMS’s own Dr Mercy Ofyua, has been awarded her PhD: ‘Dichotomisation of Continuous Outcomes in Medical Research’.
Congratulations to UMS member, Professor Janet Peacock, who has been appointed a National Institute Health Research (NIHR) Senior Investigator.
Read more about this great achievement here=
Rachel Phillips, along with colleagues, published this week in JAMA Psychiatry a meta-analysis study titled: Efficacy of Self-guided Internet-Based Cognitive Behavioral Therapy in the Treatment of Depressive Symptoms: A Meta-analysis of Individual Participant Data
The study aimed to ‘estimate the effect of self-guided internet-nased cognitive behavioural therapy (iCBT) in treating adults with depressive symptoms compared with controls and evaluate the moderating effects of treatment outcome and response’.
The authors concluded through thier extensive meta-analysis that ‘self-guided iCBT is effective in treating depressive symptoms’.
UMS member, Professor Peacock, publishes with collaborators from Dartmouth College US , a study which shows evidence that the benefits of vitamin D supplementation for the prevention of colorectal cancer varies according to vitamin D receptor genotype.
The study, titled ‘Vitamin D Receptor Genotype, Vitamin D3 Supplementation,and Risk of Colorectal Adenomas: A Randomized Clinical Trial’, has been published in JAMA Oncology.
UMS members, Dr Ayis and Professor Peacock, along with colleagues, publish in Shock this month. The study is titled: ‘Cardiac troponin release is associated with biomarkers of inflammation and ventricular dilatation during critical illness’.
The observational cohort study enrolled adult patients who were in Intensive Care Units (ICU) in two hospitals for non-caridac reasons. The study explored the possible ‘association between cardiac troponin T (cTnT) and biomarkers of systemic inflammation and ventricular dilatation’.
The authors concluded that ‘in ICU patients admitted for non-cardiac reasons, serial cTnT levels were independently associated with markers of systemic inflammation and NT-proBNP’.
Published in European Psychiatry, Dr Ayis, along with colleagues have investigated the ‘Cardiovascular risk factors among patients with schizophrenia, bipolar, depressive, anxiety, and personality disorder‘.
The authors concluded that ‘cardiovascular risk factors require special clinical attention among patients with psychiatric disorders. Further research could study the effect of antidepressants and antipsychotics on cardiovascular risk factors‘.
MedStats team member, Dr Ayis, along with colleagues publishes researching ‘Assessing the relationship between chronic pain and cardiovascular disease: A systematic review and meta-analysis‘.
The authors concluded that their ‘review supports a possible dose-response type of association between chronic pain and cardiovascular disease, supported by a range of observational studies originating from different countries‘.
MedStats team member, Dr Douiri, along with colleagues publishes study titled: ‘A prediction model for the response to oral labetalol for the treatment of antenatal hypertension’.
The study used a prospective observational design to ‘identify at presentation the maternal hemodynamic and demographic variables associated with a therapeutic response to oral labetalol and to use these variables to develop a prediction model to anticipate the response to labetalol monotherapy in women with hypertension’. The authors concluded that ‘maternal demographics and haemodynamics are potent predictors for the response to labetalol, and these parameters may guide therapy to enable effective blood pressure control and a lowering of severe hypertension rates’.
MedStats team members, Dr Peacock and Dr Douiri publish a study titled: ‘Intradermal Grass Pollen Allergen Immunotherapy for Seasonal Allergy: A Randomized Controlled Trial’
The study aimed to ‘evaluate the efficacy and safety of grass pollen intradermal immunotherapy in the treatment of allergic rhinitis’. Using a randomized control trial, the authors concluded that ‘intradermal allergen immunotherapy suppressed skin late responses but was not clinically effective and resulted in worsening of respiratory allergic symptoms’.
Dr Douiri, along with colleagues, has published a protocol in BMJ Open titled: ‘OPTIMUM: a protocol for a multicentre randomised controlled trial comparing Out Patient Talc slurry via Indwelling pleural catheter for Malignant pleural effusion vs Usual inpatient Management’.
Key Strengths and Limitations from the study were highlighted:
- This is the first prospective randomised con- trolled trial primarily comparing quality of life (QoL) outcomes between inpatient and out- patient treatment pathways for malignant pleural effusion.
- The primary outcome measure is clinically relevant.
- Patients with non-expandable lung are also included in the study.
- The study represents real life presentation and management.
- A limitation is that patients with poor perform- ance status are not included and only patients with potential for ambulatory management are included. However, to include those patient groups a separate study design to answer that specific question will have to be conducted.
Dr Douiri, along with colleagues, has published in BMJ Open a study titled: ‘Desensitisation to cigarette package graphic health warnings: a cohort comparison between London and Singapore’.
The study ‘compared 2 sociocultural cohorts with different duration of exposure to graphic health warning labels (GHWL), to investigate a possible desensitisation to their use’ and ‘studied how a differing awareness and emotional impact of smoking- associated risks could be used to prevent this’. The authors concluded that ‘length of exposure to GHWL impacts on the effectiveness. However, acknowledging the different levels of awareness and emotional impact of smoking-associated risks within different sociocultural cohorts could be used to maintain their impact’.
The Journal of Infection has published a study titled ‘Baseline cytokine profiling identifies novel risk factors for invasive fungal disease among haematology patients undergoing intensive chemotherapy or haematopoietic stem cell transplantation‘. MedStats team member, Dr Douiri, was a co-author.
The study aimed to identify cytokine profiles that correlate with increased risk of invasive fungal disease (IFD). The authors concluded that ‘high baseline IL-2R and CCL2 concentrations were independent indicators of the risk of developing IFD and could be used to identify patients for enhanced prophylaxis and early antifungal therapy’.
Dr Douiri has recently published (along with colleagues) a study titled: ‘Survival in adults with sickle cell disease in a high-income setting’ in Blood.
The study evaluated ‘survival among adult patients with SCD [sickle cell disease] followed at a single center in the United Kingdom.’ The retrospective analysis concluded that ‘although life expectancy for a patient with SCD in the United Kingdom continues to improve, it still falls behind that in the general population in London’.
MedStats team member, Dr Crichton, publishes along with collegues a study in Stroke titled: ‘Effect of Exhaust- and Nonexhaust-Related Components of Particulate Matter on Long-Term Survival After Stroke’
The study using data from the South London Stroke Register concluded that ‘exposure to certain outdoor PM pollution, particularly PM2.5, increased mortality risk poststroke up to 5 years after the initial stroke’.
Dr Douiri (MedStats team member) publishes, along with colleagues in Critical Care Medicine, a study titled: ‘Effect of Continuous Renal Replacement Therapy on Outcome in Pediatric Acute Liver Failure’
The study aimed to ‘establish the effect of continuous renal replacement therapy on outcome in pediatric acute liver failure’. Using a retrospective cohort design the authors concluded that ‘Continuous renal replacement therapy can be used successfully in critically ill children with pediatric acute liver failure to provide stability and bridge to transplantation’.
MedStats member, Dr Douiri, and colleagues have published a study titled: ‘Physiotherapy, and speech and language therapy intervention for patients with refractory chronic cough: a multicentre randomised control trial’
The study investigated whether physiotherapy, and speech and language therapy intervention (PSALTI) is effective for patients with refractory chronic cough. Using a multi-centred randomised controlled trial, the study found that PSALTI ‘significantly reduced objective cough frequency and significantly improved health related quality of life when compared with control intervention’.
Congratulations to Fiona Reid, Senior Lecturer in Medical Statistics, who recently became a Senior Fellow of the Higher Education Academy.
Her reflective portfolio looked at a pedagogy for teaching applied statistics to medical students and health professionals; the lessons for academic teaching from the world of outdoor education; and the challenges of developing a postgraduate framework for sharing core research modules across courses.