MedStats team member, Dr Crichton, publishes along with collegues a study in Stroke titled: ‘Effect of Exhaust- and Nonexhaust-Related Components of Particulate Matter on Long-Term Survival After Stroke’
The study using data from the South London Stroke Register concluded that ‘exposure to certain outdoor PM pollution, particularly PM2.5, increased mortality risk poststroke up to 5 years after the initial stroke’.
Dr Douiri (MedStats team member) publishes, along with colleagues in Critical Care Medicine, a study titled: ‘Effect of Continuous Renal Replacement Therapy on Outcome in Pediatric Acute Liver Failure’
The study aimed to ‘establish the effect of continuous renal replacement therapy on outcome in pediatric acute liver failure’. Using a retrospective cohort design the authors concluded that ‘Continuous renal replacement therapy can be used successfully in critically ill children with pediatric acute liver failure to provide stability and bridge to transplantation’.
MedStats member, Dr Douiri, and colleagues have published a study titled: ‘Physiotherapy, and speech and language therapy intervention for patients with refractory chronic cough: a multicentre randomised control trial’
The study investigated whether physiotherapy, and speech and language therapy intervention (PSALTI) is effective for patients with refractory chronic cough. Using a multi-centred randomised controlled trial, the study found that PSALTI ‘significantly reduced objective cough frequency and significantly improved health related quality of life when compared with control intervention’.
Congratulations to Fiona Reid, Senior Lecturer in Medical Statistics, who recently became a Senior Fellow of the Higher Education Academy.
Her reflective portfolio looked at a pedagogy for teaching applied statistics to medical students and health professionals; the lessons for academic teaching from the world of outdoor education; and the challenges of developing a postgraduate framework for sharing core research modules across courses.
UMS member Professor Peacock collaborates with colleagues from Dartmouth College US on study published in the Journal of Nutrition.
The study is titled: Lifestyle and other factors explain one-half of the variability in the Serum 25-Hydroxyvitamin D response to cholesterol supplementation in health adults.
Researchers concluded that ‘the factors that most affected changes in serum 25(OH)D concentrations in response to cholecalciferol supplementation included sex, baseline serum 25(OH)D, supplement intake adherence, skin-covering clothes, physical activity, and season. Genetic factors did not play a major role’.
UMS Statisticians, Dr Summers, Dr Douiri, Dr Wang, Dr Ayis, and Professor Peacock along with colleagues from Kings Technology Evaluation Centre (KiTEC) published this week in Applied Health Economics and Health Policy.
The study, as part of a NICE Medical Technology Guidance, investigated the use of Virtual Touch Quantification (VTR) to diagnose and monitor liver fibrosis in Hepatitis B and C.
In September 2015, NICE issued final guidance (MTG27) on this technology specifically in relation to liver fibrosis in patients with chronic hepatitis B or hepatitis C, and this study summarised this guidance and the evaluation process.
The study listed the following key points for decision makers:
- Virtual Touch™ Quantification (VTq) is a software application used with Siemens Acuson ultrasound scanners to assess the stiffness of liver tissue and the stage of liver fibrosis.
- The National Institute for Health and Care Excellence Medical Technology Evaluation Programme assessed the VTq software for use in people with hepatitis B or C and the External Assessment Centre estimated cost savings per patient for the VTq software in hepatitis patients was £53 when compared to transient elastography and £434 when compared to liver biopsy.
- In September 2015, the VTq software was recommended for adoption within the National Health Service (NHS) for patients with hepatitis B or C for diagnosis and monitoring of liver fibrosis.
Professor Peacock, as part of a collaboration with Dartmouth College US in Clinical trial methodology (funded by NIH), has pubslihed a study in Trials as senior author.
The study examines what factors might predict patients who will fail the run-in period that some drug trials have. This is important as if we knew why patients failed we might be able to stop it happening, which would then save time and money and gain a more representative sample included in trials.
MedStats member Dr Wang is joint lead author of a study published this week in the Lancet titled: ‘Development and validation of a dynamic outcome prediction model for paracetamol-induced acute liver failure: a cohort study‘
The study funded by the Foundation for Liver Research developed prediction models for survival of patients will paracetamol-induced liver failure, and concluded that ‘the role and indications for emergency liver transplantation in paracetamol- induced acute liver failure require re-evaluation’.
Good News: PhD Success
Well done to Dr Siobhan Crichton who has been awarded her PhD for ‘Methods for handling missing data in a population based cohort study’!
MedStats team members, Jennifer Summers, Janet Peacock, Bola Coker, Mercy Ofuya and Fiona Reid, along with colleagues, published results of their prospective survey of the provision and practise of SeHCAT (tauroselcholic [75 selenium] acid) for the diagnosis of Bile Acid Malabsorption.
The study was published in BMJ Open Gastroenterology.
The study was designed as a service evaluation of n=38 centres in the UK and captured both centre and patient-level information; such as patient care-pathways, clinical history, SeHCAT results, treatment and aspects of follow-up.
The study ‘identified a lack of consistent cut-off/threshold values, with differing centre criteria for defining an ‘abnormal’ SeHCAT result’.
Siobhan Crichton, a member of the Medical Statistics team, recently presented at Stoke Action 2016, held in Barcelona, Spain, and organised by the Spanish stroke federation.
Her pre-conference talk was on the global impact of stroke
Alessandra is a statistician who has recently joined the Unit for Medical Statistics. Prior to joining Kings she was a statistical consultant for a medical research institute in Australia, providing support to biomedical and public health researchers.
She has an undergraduate degree in Science and a Masters degree in Statistics from the University of Auckland, New Zealand.Her recent publications can be found here.
The study was published in the BMJ Open this month and was titled: ‘Variation in adverse drug reactions listed in product information for antidepressants and anticonvulsants, between the USA and Europe: a comparison review of paired regulatory documents‘.
Dr Victoria Cornelius (former member of the Medstats team, now at Imperial College) lead the study, along with Dr Kun Liu (Medstats member), Prof Janet Peacock (Medstats member) and Dr Odile Sauzet (associate member of the MedStats team).
This paper was dedicated to Kun Liu, our dear colleague, who sadly died in December 2015.
The comparison review study found notable variation in the product information sheets that list and describe adverse events for drugs between the UK and US versions. The authors suggest that this has implications for what is recognised as an adverse event and information which is given to patients.
Dr Ayis and Ms Crichton, along with co-authors from the Division of Health and Social Care Research at King’s College London, published the following article: ‘The natural history of depression and trajectories of symptoms long term after stroke: The prospective south London stroke register’.
The study in the Journal of Affective Disorders tested the hypotheses that there are different trajectories of symptoms after stroke. Data was obtained from the South London Stroke Register (1998-2013).
Highlights from the study:
- ‘Four patterns of development in depression symptoms after stroke were identified.’
- ‘Mechanisms of change in symptoms over time vary across the four patterns.’
- ‘For appropriate and timely interventions the varying needs should be observed.’
MedStat members, Professor Peacock and Dr Ayis, contributed to a recently published study titled: Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants
The study, recently published in the New England Journal of Medicine, evaluated ‘whether the early introduction of allergenic foods in the diet of breast-fed infants would protect against the development of food allergy’. The trial used an intention-to-treat analysis with early introduction of potential allergenic foods at 3 months of age (rather than the UK recommended 6 months). No evidence was found for the ‘efficacy of early introduction of allergenic foods…’. Additional analysis did find evidence that in the ‘per protocol’ group, early introduction of allergenic foods was effective.
Med Stats team members, Fiona Reid, Janet Peacock, Bola Coker and Jennifer Summers, along with colleagues, have published a research protocol in the JMIR Research Protocols titled:
The protocol sets out a study design for investigating the utility of the SeHCAT (tauroselcholic [selenium-75] acid) test in the diagnostic pathway for Bile Acid Malabsorption (BAM), a common cause of chronic diarrhoea.
MedStats members, Professor Peacock and Dr Summers contributed to a diagnostic accuracy study titled:
The study, consisting of a systematic review and meta-analysis, was published in the European Journal of Nuclear Medicine and Molecular Imaging.
MedStats member, Dr Abdel Douiri, recently helped to organise and present a workshop on Diagnostic Testing and Predictive Models in the recent NCRI Cancer Conference 2015 held in Liverpool.
UMS member, Professor Peacock, and UMS associate member, Dr Sauzet in collaboration with colleagues published a qualitative analysis of pain experiences for head and neck cancer patients in the British Journal of Pain.
‘Towards a pain free hospital: an in-depth qualitative analysis of the pain experiences of head and neck cancer patients undergoing radiotherapy’ found that ‘the specific issues faced by head and neck cancer patients undergoing radiotherapy high- light the need for pain relieving interventions delivered by pain specialists, in tandem with the development of robust self-management strategies.
British Journal of Pain September 23, 2015