UMS member Rachel Phillips publishes in JAMA Psychiatry

Rachel Phillips, along with colleagues, published this week in JAMA Psychiatry a meta-analysis study titled: Efficacy of Self-guided Internet-Based Cognitive Behavioral Therapy in the Treatment of Depressive SymptomsA Meta-analysis of Individual Participant Data

The study aimed to ‘estimate the effect of self-guided internet-nased cognitive behavioural therapy (iCBT) in treating adults with depressive symptoms compared with controls and evaluate the moderating effects of treatment outcome and response’.

The authors concluded through thier extensive meta-analysis that ‘self-guided iCBT is effective in treating depressive symptoms’.

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Professor Peacock publishes in JAMA Oncology

UMS member, Professor Peacock, publishes with collaborators from Dartmouth College US , a study which shows evidence that the benefits of vitamin D supplementation for the prevention of colorectal cancer varies according to vitamin D receptor genotype.

The study, titled ‘Vitamin D Receptor Genotype, Vitamin D3 Supplementation,and Risk of Colorectal Adenomas: A Randomized Clinical Trial’, has been published in JAMA Oncology.

Dr Ayis and Prof Peacock publish in Shock

UMS members, Dr Ayis and Professor Peacock, along with colleagues, publish in Shock this month. The study is titled: ‘Cardiac troponin release is associated with biomarkers of inflammation and ventricular dilatation during critical illness’.

The observational cohort study enrolled adult patients who were in Intensive Care Units (ICU) in two hospitals for non-caridac reasons. The study explored the possible ‘association between cardiac troponin T (cTnT) and biomarkers of systemic inflammation and ventricular dilatation’.

The authors concluded that ‘in ICU patients admitted for non-cardiac reasons, serial cTnT levels were independently associated with markers of systemic inflammation and NT-proBNP’.

Dr Ayis investigates cardiovscular risk factors amongst patients with psychiatric disorders

Published in European Psychiatry, Dr Ayis, along with colleagues have investigated the ‘Cardiovascular risk factors among patients with schizophrenia, bipolar, depressive, anxiety, and personality disorder‘.

The authors concluded that ‘cardiovascular risk factors require special clinical attention among patients with psychiatric disorders. Further research could study the effect of antidepressants and antipsychotics on cardiovascular risk factors‘.

Dr Ayis publishes systematic review and meta-analysis in Scandinavian Journal of Pain

MedStats team member, Dr Ayis, along with colleagues publishes researching ‘Assessing the relationship between chronic pain and cardiovascular disease: A systematic review and meta-analysis‘.

The authors concluded that their ‘review supports a possible dose-response type of association between chronic pain and cardiovascular disease, supported by a range of observational studies originating from different countries‘.

 

 

Dr Douiri publishes in the Journal of Hypertension

MedStats team member, Dr Douiri, along with colleagues publishes study titled: ‘A prediction model for the response to oral labetalol for the treatment of antenatal hypertension’.

The study used a prospective observational design to ‘identify at presentation the maternal hemodynamic and demographic variables associated with a therapeutic response to oral labetalol and to use these variables to develop a prediction model to anticipate the response to labetalol monotherapy in women with hypertension’. The authors concluded that ‘maternal demographics and haemodynamics are potent predictors for the response to labetalol, and these parameters may guide therapy to enable effective blood pressure control and a lowering of severe hypertension rates’.

Dr Peacock and Dr Douiri publish in the Journal of Allergy and Clinical Immunology

MedStats team members, Dr Peacock and Dr Douiri publish a study titled: ‘Intradermal Grass Pollen Allergen Immunotherapy for Seasonal Allergy: A Randomized Controlled Trial’

The study aimed to ‘evaluate the efficacy and safety of grass pollen intradermal immunotherapy in the treatment of allergic rhinitis’. Using a randomized control trial, the authors concluded that ‘intradermal allergen immunotherapy suppressed skin late responses but was not clinically effective and resulted in worsening of respiratory allergic symptoms’.

 

MedStats team member, Dr Douiri, publishes protocol paper in BMJ Open

Dr Douiri, along with colleagues, has published a protocol in BMJ Open titled: ‘OPTIMUM: a protocol for a multicentre randomised controlled trial comparing Out Patient Talc slurry via Indwelling pleural catheter for Malignant pleural effusion vs Usual inpatient Management’.

Key Strengths and Limitations from the study were highlighted:

  • This is the first prospective randomised con- trolled trial primarily comparing quality of life (QoL) outcomes between inpatient and out- patient treatment pathways for malignant pleural effusion.
  • The primary outcome measure is clinically relevant.
  • Patients with non-expandable lung are also included in the study.
  • The study represents real life presentation and management.
  • A limitation is that patients with poor perform- ance status are not included and only patients with potential for ambulatory management are included. However, to include those patient groups a separate study design to answer that specific question will have to be conducted.

 

Dr Douiri publishes in BMJ Open

Dr Douiri, along with colleagues, has published in BMJ Open a study titled: ‘Desensitisation to cigarette package graphic health warnings: a cohort comparison between London and Singapore’.

The study ‘compared 2 sociocultural cohorts with different duration of exposure to graphic health warning labels (GHWL), to investigate a possible desensitisation to their use’ and ‘studied how a differing awareness and emotional impact of smoking- associated risks could be used to prevent this’. The authors concluded that ‘length of exposure to GHWL impacts on the effectiveness. However, acknowledging the different levels of awareness and emotional impact of smoking-associated risks within different sociocultural cohorts could be used to maintain their impact’.

 

 

MedStats member, Dr Douiri, publishes in the Journal of Infection

The Journal of Infection has published a study titled ‘Baseline cytokine profiling identifies novel risk factors for invasive fungal disease among haematology patients undergoing intensive chemotherapy or haematopoietic stem cell transplantation‘. MedStats team member, Dr Douiri, was a co-author.

The study aimed to identify cytokine profiles that correlate with increased risk of invasive fungal disease (IFD). The authors concluded that ‘high baseline IL-2R and CCL2 concentrations were independent indicators of the risk of developing IFD and could be used to identify patients for enhanced prophylaxis and early antifungal therapy’.

Dr Douiri publsihes in the journal of Blood

Dr Douiri has recently published (along with colleagues) a study titled: ‘Survival in adults with sickle cell disease in a high-income setting’ in Blood.

The study evaluated ‘survival among adult patients with SCD [sickle cell disease] followed at a single center in the United Kingdom.’ The retrospective analysis concluded that ‘although life expectancy for a patient with SCD in the United Kingdom continues to improve, it still falls behind that in the general population in London’.

Dr Crichton publishes in Stroke

MedStats team member, Dr Crichton, publishes along with collegues a study in Stroke titled: ‘Effect of Exhaust- and Nonexhaust-Related Components of Particulate Matter on Long-Term Survival After Stroke’

The study using data from the South London Stroke Register concluded that ‘exposure to certain outdoor PM pollution, particularly PM2.5, increased mortality risk poststroke up to 5 years after the initial stroke’.

Dr Douiri publishes in Critical Care Medicine

Dr Douiri (MedStats team member) publishes, along with colleagues in Critical Care Medicine, a study titled: ‘Effect of Continuous Renal Replacement Therapy on Outcome in Pediatric Acute Liver Failure’

The study aimed to ‘establish the effect of continuous renal replacement therapy on outcome in pediatric acute liver failure’. Using a retrospective cohort design the authors concluded that ‘Continuous renal replacement therapy can be used successfully in critically ill children with pediatric acute liver failure to provide stability and bridge to transplantation’.

Dr Douiri publishes in Thorax (part of BMJ group)

MedStats member, Dr Douiri, and colleagues have published a study titled: ‘Physiotherapy, and speech and language therapy intervention for patients with refractory chronic cough: a multicentre randomised control trial’

The study investigated whether physiotherapy, and speech and language therapy intervention (PSALTI) is effective for patients with refractory chronic cough. Using a multi-centred randomised controlled trial, the study found that PSALTI ‘significantly reduced objective cough frequency and significantly improved health related quality of life when compared with control intervention’.

 

UMS member Fiona Reid appointed as Senior Fellow of the Higher Education Academy

Congratulations to Fiona Reid, Senior Lecturer in Medical Statistics, who recently became a Senior Fellow of the Higher Education Academy.

Her reflective portfolio looked at a pedagogy for teaching applied statistics to medical students and health professionals; the lessons for academic teaching from the world of outdoor education; and the challenges of developing a postgraduate framework for sharing core research modules across courses.

Professor Peacock collaborates on research with Dartmouth College US

UMS member Professor Peacock collaborates with colleagues from Dartmouth College US on study published in the Journal of Nutrition.

The study is titled:  Lifestyle and other factors explain one-half of the variability in the Serum 25-Hydroxyvitamin D response to cholesterol supplementation in health adults.

Researchers concluded that ‘the factors that most affected changes in serum 25(OH)D concentrations in response to cholecalciferol supplementation included sex, baseline serum 25(OH)D, supplement intake adherence, skin-covering clothes, physical activity, and season. Genetic factors did not play a major role’.

UMS Statisticians publish study on liver fibrosis for a NICE Guidance

UMS Statisticians, Dr Summers, Dr Douiri, Dr Wang, Dr Ayis, and Professor Peacock along with colleagues from Kings Technology Evaluation Centre (KiTEC) published this week in Applied Health Economics and Health Policy.

The study, as part of a NICE Medical Technology Guidance, investigated the use of Virtual Touch Quantification (VTR) to diagnose and monitor liver fibrosis in Hepatitis B and C.

In September 2015, NICE issued final guidance (MTG27) on this technology specifically in relation to liver fibrosis in patients with chronic hepatitis B or hepatitis C, and this study summarised this guidance and the evaluation process.

The study listed the following key points for decision makers:

  • Virtual Touch™ Quantification (VTq) is a software application used with Siemens Acuson ultrasound scanners to assess the stiffness of liver tissue and the stage of liver fibrosis.
  • The National Institute for Health and Care Excellence Medical Technology Evaluation Programme assessed the VTq software for use in people with hepatitis B or C and the External Assessment Centre estimated cost savings per patient for the VTq software in hepatitis patients was £53 when compared to transient elastography and £434 when compared to liver biopsy.
  • In September 2015, the VTq software was recommended for adoption within the National Health Service (NHS) for patients with hepatitis B or C for diagnosis and monitoring of liver fibrosis.

Professor Peacock publishes in Trials

Professor Peacock, as part of a collaboration with Dartmouth College US in Clinical trial methodology (funded by NIH), has pubslihed a study in Trials as senior author.

The study examines what factors might predict patients who will fail the run-in period that some drug trials have. This is important as if we knew why patients failed we might be able to stop it happening, which would then save time and money and gain a more representative sample included in trials.

Dr Wang published in Lancet

MedStats member Dr Wang is joint lead author of a study published this week in the Lancet titled: ‘Development and validation of a dynamic outcome prediction model for paracetamol-induced acute liver failure: a cohort study

The study funded by the Foundation for Liver Research developed prediction models for survival of patients will paracetamol-induced liver failure, and concluded that ‘the role and indications for emergency liver transplantation in paracetamol- induced acute liver failure require re-evaluation’.